Director, Tax
Straight from Definium Therapeutics’s careers page. Apply on the company site — no recruiter, no middleman.
Director, Tax
Location: Hybrid
Department: 12 - Finance
Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.
Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.
Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.
Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!
In this role, you will develop and execute Definiums tax strategy as we transition from a development-stage to a commercial-stage company. As our primary internal tax resource and trusted advisor to Finance leadership, you will oversee tax accounting and planning, coordinate compliance through external advisors, and build the infrastructure to support commercial operations. The ideal candidate pairs strong technical expertise with a practical, business-oriented approach and is comfortable leading strategy and executing hands-on.
Responsibilities:
- Lead Definiums tax strategy and planning, including the tax impact of financings, equity compensation, corporate structure changes, and strategic transactions
- Own ASC 740 tax accounting, including quarterly and annual provisions, deferred tax assets, valuation allowances, and uncertain tax positions, in support of SEC reporting and audits
- Oversee federal, state, local, and international compliance performed by external providers, and coordinate responses to tax authority inquiries
- Lead tax readiness for commercialization, including state and local, sales and use, franchise, and nexus considerations for a growing field-based and commercial workforce
- Manage tax attributes and credits, including Section 382 analyses, NOL preservation, and federal and state R&D credit studies
- Support business development, licensing, and collaboration transactions, plus transfer pricing and legal entity planning as needed
- Serve as principal liaison to external tax advisors, managing workstreams, budgets, and deliverables, and challenging recommendations as needed
- Partner with Accounting, FP&A, Treasury, Legal, Payroll, HR, Commercial, and Executive Leadership, and build scalable tax processes, policies, and documentation
Qualifications:
- Minimum bachelors degree in accounting, Finance, Tax, or a related field required; Masters in Taxation (MST) or advanced tax credential preferred
- CPA certification required
- Minimum 10 years of progressive tax experience required
- Strong knowledge of ASC 740 and U.S. corporate taxation required
- Experience supporting public company reporting and managing external tax service providers required
- Strong project management, organizational, and communication skills, with the ability to balance strategy and hands-on execution
- Up to 10% travel will be required based upon business needs
Preferred:
- Big Four or national public accounting experience
- Biotech, pharmaceutical, life sciences, or healthcare industry experience
- Experience supporting organizations transitioning from development-stage to commercial operations.
- Experience with Section 382, NOL planning, R&D credits, multi-state taxation, equity compensation, and capital markets transactions
Individual compensation within the range is determined based on factors such as relevant skills, experience, qualifications, scope of the role, and other legitimate business considerations. In addition to base salary, this role may be eligible for bonus and equity opportunities. We also offer a comprehensive benefits package including health insurance, 401(k) with company match, flexible time off and additional wellness benefits and perks. Learn more about our benefits on our Careers page.
Similar remote jobs
More like this →
CoLab Software
Senior Director, Talent Acquisition (Remote)

Definium Therapeutics
Regional Director, Site Engagement & Access (Remote)

Definium Therapeutics
Director, Medical Marketing

Definium Therapeutics
Director, Market Research, Competitive Intelligence & Forecasting (Remote)
Discover More than 100,000 Hidden Remote Jobs Before Everyone Else
Unlock All Remote Jobs Today
Simple pricing. Big savings on Quarterly and Yearly.
Monthly Access
- Instant access to fresh remote jobs from 500+ companies
- New opportunities added hourly, often 3-7 days before anywhere else
- Advanced filtering by role type, stack, pay, and location
- Priority customer support
Yearly Access
- Everything in Monthly
- Save $169 (~74%) vs paying monthly
- Average job search takes ~6 months - get covered for the whole journey
- Less than the cost of one lunch per month for competitive advantage
- Equivalent to just ~$4.92/month