Senior Manager, Technical Clinical Data Management

Location: Waltham, MA, us, Remote

Company Description

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. Learn more about Deciphera, a member of Ono Pharmaceutical Co., Ltd., by visiting our website: https://deciphera.com

Job Description

We are seeking an experienced Senior Manager, Technical Clinical Data Management to take full accountability for end-to-end data management lifecycle activities across assigned clinical trials. In this dual-function role, the individual will serve as the primary Data Management Study Lead, managing timelines, cross-functional communication, risks, and deliverables while also applying hands-on technical expertise. Candidate will combine strong clinical data management leadership with the technical ability to design efficient, scalable solutions that improve data quality, accelerate issue resolution, and support timely study delivery.

Key Responsibilities:
Clinical Data Management Leadership & Technical Operations 

Leadership & Study Oversight

• Represent Data Management on the Clinical Study Team, lead study communications, and manage expectations with the Data Management CRO
• Oversee all activities defined in the Data Management Plan (DMP) and ensure study deliverables meet quality and timeline expectations

Technical Operations

• Advance vendor oversight by applying data intelligence to identify trends, strengthen performance monitoring, and improve operational efficiency
• Partner with IT to streamline external data transfers and integrate data across systems for cross-functional use

Vendor & Stakeholder Management 

• Oversee outsourced CDM vendors and ensure performance aligns with Deciphera standards
• Review vendor invoices as applicable
• Collaborate with cross functional team on data deliverables

Leadership, Process & Continuous Improvement 

• Enhance CDM processes and strengthen cross functional collaboration
• Support department initiatives as needed

Inspection Readiness, Quality & Metrics 

• Lead CDM inspection activities and manage findings to resolution
• Ensure CDM documentation is complete and filed in the TMF

Other duties and responsibilities as assigned

Qualifications

• Bachelors or masters degree with 8+ years of experience in Clinical Data Management
• Knowledge of FDA/CFR and ICH/GCP
• Familiarity of CDISC and CDASH standards
• Experience with data visualization tools to build study-status and data quality dashboards
• Experience creating and applying tools to clinical data workflows, including data review, automation, and visualization with appropriate validation and human oversight
• Familiarity with AI (e.g. Copilot, Claude)
• Effective communication, organizational, and project management skills

Preferred Capabilities:

•  Experience building in Medidata RAVE
•  Hands on experience using SAS for data extraction and validation
•  Experience with J-Review

Additional Information

Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $164,000 - $200,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.

Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)

Benefits:

• Competitive salary and annual bonus.
• Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
• Generous parental leave and family planning benefits.
• Outstanding culture and opportunities for personal and professional growth.

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION

Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.