<div><p><span><span>Position Summary: </span></span>Terray is currently seeking a motivated, creative, and experienced scientist to join our molecular design group. As an integral member of the Computational and Data Sciences (CDS) team, the candidate will guide design efforts to follow up on hits and advance programs into lead optimization, leveraging our vast chemical datasets and proprietary wet-lab + computational platforms to power state-of-the-art small molecule design. In this interdisciplinary role, the candidate will work closely with the chemistry and biology functions at Terray, as well as the machine learning and data science teams within CDS. </p><div><br /></div><div>The core responsibilities of this position are: </div><ul><li><div>Design small molecules with in-house, high-throughput computational tools using both structural models and ligand-based data from our proprietary screening platform </div></li><li><div>Develop strategies to assess and progress hits across multiple programs for our internal pipeline and partnered projects </div></li><li><div>Design focus libraries to drive small molecule programs in hit-to-lead and lead optimization</div></li><li><div>Develop and evaluate models and generative tools to design compounds with desired properties in collaboration with the machine learning team </div></li><li><div>Communicate molecular design strategy and outcomes to teams across the company </div></li></ul></div><div><div><br /></div><p><span><span>Experience and Qualifications: </span></span><span><span>Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, </span><span>recognized</span><span> and empowered to be creative.</span></span><span> </span></p></div><div><p><span><span>Required Qualifications:</span></span><span> </span></p></div><div><ul><li><div><span>BS/MS/Ph.D in computational, organic, or medicinal chemistry, or a related field</span></div></li><li><div><span>Experience applying ligand-based and structure-based methods to designing small molecules for multiple drug discovery projects</span><span> </span></div></li><li><div><span>Experience working with medicinal chemists to optimize ADME and safety issues</span><span> </span></div></li><li><div><span>Experience triaging large data sets from virtual screens, DEL screens, and/or HTS</span><span> </span></div></li><li><div><span>Experience with RDKit, molecular simulation suites (Schrodinger, MOE, etc.), and docking programs (AutoDock Vina, rDock, etc.)</span><span> </span></div></li><li><div><span>Proficient in Python and the PyData stack (numpy, pandas, scipy, scikit-learn, etc.)</span><span> </span></div></li></ul><div><br /><strong>Compensation Details:</strong><span><span> $</span></span><span><span>160,000 - $240,000</span></span><span><span> </span><span>(annually) depending on seniority; participation in the Companys option plan; 3% </span><span>retirement safe harbor</span><span> contribution; </span><span>full</span><span>y</span><span>-</span><span>paid</span><span> medical, dental, vision, </span><span>life</span><span> and disability</span><span> benefits</span><span>.</span></span><span> </span> </div></div>

Terray Therapeutics

Senior Scientist, Molecular Design

Terray Therapeutics