<div>Spyre Therapeutics is a clinical-stage biotechnology company that aims to create next-generation inflammatory bowel disease (IBD) and other immune-mediated disease products by combining best-in-class antibody engineering, dose optimization, and rational therapeutic combinations. Spyres pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.</div>Role Summary: Reporting to the VP, Medical Affairs, the Medical Science Liaison is a therapeutic/disease expert responsible for scientific engagement with Thought Leaders and study investigators in achieving improved health outcomes for patients. This individual will provide strategic medical leadership within the Medical Affairs organization, ensuring scientific integrity, regulatory compliance, and effective communication between healthcare professionals, research teams, and business stakeholders. This role supports product development, clinical research, and medical education while driving evidence-based strategies to enhance patient care. This individual will be responsible for other field-based workstreams including local and national medical conference planning, investigator meeting support, advocacy organization engagement and advisory board participation. Key Responsibilities: <ul> <li>Support research initiatives across development; provide support to clinical site investigators as needed</li> <li>Foster collaboration, trust and efficiency ensuring timely recruitment, high quality data and protocol adherence while supporting investigators and site staff.</li> <li>Recommend study sites and identifies potential investigators to participate in Clinical Development programs.</li> <li>Identify and engage Thought Leaders, active and potential study investigators, providers at academic and non-academic institutions and professional organizations within assigned geography.</li> <li>Effectively articulate relevant scientific and clinical information relative to therapeutic area and Spyre’s product life cycle to Thought Leaders and researchers.</li> <li>Ensure compliance with regulatory and ethical guidelines in medical communications</li> <li>Develop and oversee medical education programs and advisory boards.</li> <li>Stay up to date with industry trends, clinical advancements, and competitive intelligence to provide strategic insights.</li> <li>Represent the organization at conferences, medical symposia, and external meetings to facilitate exchange of scientific information with internal and external stakeholders.</li> <li>Identify issues related to patient enrollment and retention efforts in planned or ongoing company-sponsored clinical studies and communicates insights to Clinical Development team.</li> <li>Other duties as assigned.</li> </ul> Ideal Candidate: <ul> <li>PharmD, MD, PhD or similar with 3+ years of MSL experience.</li> <li>IBD and/or Rheumatology experience required.</li> <li>Strong understanding of drug development processes, regulatory requirements, compliance and healthcare trends.</li> <li>Excellent communication and leadership skills with the ability to engage diverse stakeholders.</li> <li>Strong team player with a demonstrated track record of success in a cross‐functional team and fast-moving environment.</li> </ul>  Work Location and Travel Requirements: <ul> <li>This is a field-based position.</li> <li>Frequent travel with some overnight stay is required.</li> <li>This position requires the ability to drive within the assigned geographic territory by automobile and to travel by airplane or train.</li> <li>Occasional international air travel with multi-night stays.</li> </ul> What We Offer: <ul> <li>Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.</li> <li>Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare &amp; retirement benefits.</li> <li>Unlimited PTO</li> <li>Two, one-week company-wide shutdowns each</li> <li>Commitment to provide professional development opportunities.</li> <li>Remote working environment with frequent in-person meetings to address complex problems and build relationships.</li> </ul> The expected salary range offer for this role is $225,000 to $241,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. <div>As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients. Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email. Please also be aware that all job postings will be listed on our website at spyre.com/careers/.</div>