<div>Spyre Therapeutics is a clinical-stage biotechnology company that aims to create next-generation inflammatory bowel disease (IBD) and other immune-mediated disease products by combining best-in-class antibody engineering, dose optimization, and rational therapeutic combinations. Spyres pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.</div>Role Summary: The Director of Clinical Pharmacology will play a pivotal role in leading our clinical pharmacology efforts to advance the development of our cutting-edge antibody portfolio. This position requires a strategic leader who can integrate clinical pharmacology and model-informed approaches into our drug development programs to ensure efficacy, safety, and regulatory success. Key Responsibilities: <ul> <li>Lead the strategic planning and execution of clinical pharmacology analyses, including population and PK/PD and exposure-response modeling to support dose selection and clinical trial design.</li> <li>Collaborate closely with cross-functional teams, including clinical development, non-clinical development, DMPK, regulatory affairs, and clinical operations, to ensure alignment and integration of clinical pharmacology principles throughout the drug development process.</li> <li>Manage and collaborate with pharmacometrics vendors to support the pipeline.</li> <li>Support clinical pharmacology sections of regulatory submissions and interactions with health authorities worldwide.</li> <li>Stay abreast of emerging trends and regulations in clinical pharmacology and antibody development to ensure Spyre Therapeutics remains at the cutting edge.</li> <li>Additional duties as assigned. </li> </ul> Ideal Candidate: <ul> <li>Doctoral degree (MD/Ph.D./Pharm D) in Pharmacology, Pharmaceutical Sciences, or related field, with a strong focus on clinical pharmacology.</li> <li>A minimum of 5+ years of experience in clinical pharmacology within the pharmaceutical or biotechnology industry, with significant experience in protein therapeutics.  Experience with extended half-life biologics and/or combination products desirable.</li> <li>Fast and curious learner that thrives in fast-paced dynamic environment, with a proven ability to excel amid rapid change and shifting priorities.</li> <li>Proven track record of accomplishment in drug development, from early-stage research through to regulatory submission and approval.</li> <li>Experience with regulatory submissions and interactions with health authorities.</li> <li>Strong analytical and problem-solving skills, with expertise in PK/PD modeling and simulation, including Phoenix, R, and NONMEM.</li> <li>Excellent communication and interpersonal skills, with the ability to collaborate effectively across functions.</li> </ul> What We Offer: <ul> <li>Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.</li> <li>Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare &amp; retirement benefits.</li> <li>Unlimited PTO</li> <li>Two, one-week company-wide shutdowns each</li> <li>Commitment to provide professional development opportunities.</li> <li>Remote working environment with frequent in-person meetings to address complex problems and build relationships.</li> </ul> The expected salary range offer for this role is $ 225,000 to $246,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. <div>As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients. Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email. Please also be aware that all job postings will be listed on our website at spyre.com/careers/.</div>

Spyre Therapeutics

Director, Clinical Pharmacology

Spyre Therapeutics

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