<div><b>About AQEMIA</b></div><div><br /></div><div><span>AQEMIA is a next-gen pharmatech company advancing one of the worlds fastest-growing drug discovery pipelines. Our mission is to design breakthrough drug candidates faster and smarter for critical diseases—such as immuno-oncology—by fusing </span><b>quantum-inspired physics algorithms</b><span> with </span><b>generative AI</b><span>, without relying on experimental training data. We’ve already achieved multiple preclinical milestones both internally and in collaboration with top pharmaceutical partners. Our leading programs are now in </span><b>in vivo optimization</b><span> stages. With strong financial backing and rapid pipeline growth, we’re scaling our scientific teams to double the number of active programs.</span></div><div><br /></div><div><b>Your Role as Senior Computational Drug Hunter </b></div><div><br /></div><div><span>As a Senior Computational Chemist, you will play a strategic and hands-on role across multiple drug discovery projects—from hit generation to preclinical candidate nomination. </span></div><div><span>You will:</span></div><div><span>- </span><b>Design, evaluate, and prioritize molecules</b><span> for synthesis using AQEMIA’s proprietary physics-based and AI-powered technologies.</span></div><div><span>- Drive the </span><b>computational design strategy</b><span> and ensure it remains grounded in </span><b>mechanistic hypotheses, predictive models, and SAR data</b><span>.</span></div><div><span>- Collaborate with </span><b>cross-functional teams</b><span>, including medicinal chemistry, biosciences, and AI/ML specialists, to ensure tight integration of computational insights across projects.</span></div><div><br /></div><div><span>You will operate within a dynamic and adaptive project model. Most teams include a Program Lead, a Medicinal Chemist, two Computational Chemists (each 50% allocated), and support from Biology as needed. As we grow, team structures evolve to match each program’s unique scientific challenges.</span></div><div><br /></div><div><u><b>Your Key Responsibilities</b></u></div><div><br /></div><div><b>Scientific &amp; Strategic Impact</b></div><div><span>- Act as a </span><b>computational chemistry lead</b><span> on multidisciplinary programs, guiding efforts from hit expansion through lead optimization.</span></div><div><span>- Shape program direction through </span><b>binding mode hypotheses, SAR analysis, predictive modeling</b><span>, and data-driven prioritization.</span></div><div><span>- Contribute to portfolio-wide </span><b>strategic decisions</b><span> by identifying opportunities where AQEMIA’s technologies can deliver disproportionate impact.</span></div><div><span>- Champion the integration of </span><b>physics-based simulations, free energy methods</b><span>, and machine learning models into project workflows.</span></div><div><br /></div><div><b>Platform &amp; Cross-Functional Collaboration</b></div><div><span>- Provide structured feedback to internal platform and AI/physics teams to </span><b>accelerate tool development</b><span> aligned with real-world discovery needs.</span></div><div><span>- Collaborate with leadership to </span><b>prioritize high-value scientific opportunities</b><span> across the pipeline.</span></div><div><span>- Help define </span><b>best practices</b><span> and shape AQEMIA’s computational chemistry strategy across therapeutic areas.</span></div><div><span>- Promote a culture of </span><b>scientific rigor, learning, and cross-functional mentorship</b><span> through reviews and ideation sessions.</span></div><div><br /></div><div><br /></div><div><u><b>What We’re Looking For</b></u></div><div><br /></div><div><b>Required Background &amp; Expertise</b></div><div><span>- PhD or equivalent experience in Computational Chemistry, Biophysics, Cheminformatics, or a related field.</span></div><div><span>- 5–10 years of experience in drug discovery, including at least 5 years in the drug discovery industryProven track record in small molecule structure-based and ligand-based design, SAR interpretation, and hypothesis generation.</span></div><div><span>- Proficiency in programming (Python preferred) and use of modern open-source cheminformatics and modeling tools.</span></div><div><span>- Solid understanding of physics-based methods, including molecular dynamics and free energy calculations.</span></div><div><span>- Familiarity with medicinal chemistry principles and ability to communicate fluently across disciplines.</span></div><div><br /></div><div><b>Mindset &amp; Values</b></div><div><span>- Passionate about contributing to a mission-driven biotech company changing how drugs are discovered.</span></div><div><span>- Curious, data-driven, and intellectually rigorous.</span></div><div><span>- Comfortable making strategic decisions in high-uncertainty contexts.</span></div><div><span>- Enthusiastic about sharing knowledge, and contributing to a learning organization.</span></div><div><span>- Adaptable, organized, and effective in a fast-paced, evolving environment.</span></div><div><br /></div><div><b>Why Join Us?</b></div><div><br /></div><div><span>At AQEMIA, we work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape the direction of our fast-growing company and team.</span></div><div><b>Expanding Drug Discovery Pipeline</b><span>: Focused on critical therapeutic areas like Oncology, CNS, Immuno-inflammation - with in vivo proof of concept/patent stage programs. Collaborations with top Pharma, including a $140M Sanofi deal.</span></div><div><b>Elite Collaborations</b><span>: Partnered with major pharmas, including a $140M+ collaboration with </span><b>Sanofi</b><span>.</span></div><div><b>Tech + Bio Excellence</b><span>: Be part of an interdisciplinary team combining the </span><b>best of physics, AI, chemistry, and biology</b><span>.</span></div><div><b>Strong Growth &amp; Support</b><span>: Backed by over </span><b>$100M in funding</b><span>, and named a </span><b>French Tech 120</b><span> company.</span></div><div><b>Great Locations</b><span>: Offices in central Paris and London (King’s Cross), with </span><b>2 remote days/week</b><span>.</span></div><div><b>Relocation &amp; Integration</b><span>: International environment with relocation support and French lessons offered (if needed).</span></div><div><br /></div><div><b>Our recruitment process</b></div><div><br /></div><div><span>- Screening with TA - 30mn</span></div><div><span>- First interview with the hiring manager - 45mn</span></div><div><span>- Technical case with team members - 1h30 </span></div><div><span>- Cultural fit interview with Emmanuelle Martiano, co founder and COO - 45mn</span></div><div><span>- Final interview with Maximilien Levesque, CEO - 1h</span></div>